How does the extracellular matrix direct gene expression? J. The extracellular matrix modulates the metastatic journey. Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells. Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone. The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites. TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling. Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments.
Mechanisms of cancer cell dormancy-another hallmark of cancer? Cancer Res. Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Review mechanisms governing metastatic dormancy and reactivation. The relationship between dormant cancer cells and their microenvironment. Mechanisms of disseminated cancer cell dormancy: an awakening field. Our data support the idea that the manipulation of these mechanisms could serve as a barrier to metastasis through disseminated tumor cell dormancy induction. Analysis of clinical samples revealed that type III collagen levels were increased in tumors from patients with lymph node-negative head and neck squamous cell carcinoma compared to patients who were positive for lymph node colonization. Second-harmonic generation two-photon microscopy further revealed that the dormancy-to-reactivation transition is accompanied by changes in type III collagen architecture and abundance. Tumor-derived type III collagen is required to sustain tumor dormancy, as its disruption restores tumor cell proliferation through DDR1-mediated STAT1 signaling. ECM proteomics revealed that dormant cancer cells assemble a type III collagen-enriched ECM niche. Here we studied how disseminated tumor cells sense and remodel the extracellular matrix (ECM) to sustain dormancy.
Cancer cells disseminate and seed in distant organs, where they can remain dormant for many years before forming clinically detectable metastases.
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